Saturday, March 30, 2019

Vitamin C Can Shorten the Length of Stay in the ICU: A Meta-Analysis


Link to Abstract

Full PDF available once you click the link above.

Friday, March 29, 2019

The effect of corticosteroids on mortality of patients with influenza pneumonia: a systematic review and meta-analysis



Link to Abstract

Link to PDF

Passive leg raising: five rules, not a drop of fluid!



Link to Abstract

Link to PDF

There may be such a thing as too much oxygen..

The effect of hyperoxia on mortality in critically ill patients: a systematic review and meta analysis

Do your patients have supplemental oxygen and sats of 100% on the monitor? If so, they may be getting too much oxygen. Wean the supplemental oxygen as we have data that this causes harm. I encourage you to read this article which you can download on my website, eddyjoemd.com. I’m making an effort to review articles for you all that you can download for free and not have to pay ridiculous fees to stay up to date. You can like my posts and YouTube videos and donate $10 to your favorite charity instead 😁. Thank you to the authors, as always because I do not do research myself.

-EJ


Link to Abstract

Link to PDF

Tuesday, March 26, 2019

Hyperchloremic Metabolic Acidosis and Acute Kidney Injury

Hyperchloremia and moderate increase in serum chloride are associated with acute kidney injury in severe sepsis and septic shock patients

A lot of the research I do on my own time to be a better doctor includes the simple basics of critical care. I don’t delve too much into the esoteric things bc it doesn’t impact as many lives as what I do on a DAILY basis. That’s the reason why I’m obsessed with fluids and sharing what I’ve learned along the way leading to how my practice has changed. Keep in mind that even LR could lead to an increase in the serum Cl (nl 98-109 and LR has 109mmol/L). I have made a video on YouTube describing the different fluids side by side that I made when I was a fellow. Since then, I have made individual videos covering NS, LR, and Plasma-Lyte. I really hope that some of you are benefitting from these posts. I appreciate the feedback I’ve received. Hat tip to the authors.

-EJ 



Link to Abstract

Link to PDF

Marik Protocol for Septic Shock: Looking at Vitamin C

Hydrocortisone, Ascorbic Acid and Thiamine
(HAT Therapy) for the Treatment of Sepsis. Focus on Ascorbic Acid

Controversies. Controversies. Controversies. I tell you, the behaviors of Intensivists when it comes to king septic patients IV Vitamin C for sepsis are quite perplexing. We had a cheap drug, <$20 a day that MAY help treat sepsis and people don’t even bother to try it out. I know I use it because if it saves lives, why not try? Let’s say that the trials show a mortality benefit, two years have already passed since the first trial. Think of all the additional lives you could have saved but didn’t because your ego was in the damned way. If Marik is wrong, nothing bad happened. But if he’s right, you’re going to beat yourself up.

-EJ 



Link to Abstract

Link to PDF

Articles that I have used for my Instagram Posts as of 3/25



https://jamanetwork.com/journals/jama/article-abstract/2725234



https://annalsofintensivecare.springeropen.com/articles/10.1186/s13613-019-0506-y
https://annalsofintensivecare.springeropen.com/track/pdf/10.1186/s13613-019-0506-y



https://www.nejm.org/doi/full/10.1056/NEJMoa1812405?query=pulmonary



https://onlinelibrary.wiley.com/doi/full/10.1111/anae.14472



https://ccforum.biomedcentral.com/articles/10.1186/s13054-019-2368-y
https://ccforum.biomedcentral.com/track/pdf/10.1186/s13054-019-2368-y



https://link.springer.com/epdf/10.1007/s00134-019-05561-w?shared_access_token=rTeiylWJdlL3VwqGpj4Kq_e4RwlQNchNByi7wbcMAY643av82qwwcII63__HlENh6YhUR4ZGkthQ4JdHcBeAV8Z7KNOkmV_O79HdliiumiAUAvOLvY0NPXmgLces5SGUvXWZvUJa9gprHlZMUdPakg%3D%3D



https://link.springer.com/epdf/10.1007/s00134-019-05526-z?shared_access_token=6MIrpEk5bbwEEnz4YIjB7ve4RwlQNchNByi7wbcMAY6T8cDofZacKXv6q8aKiyjTVK8EN5sZ_Tbg_x-Wvs85hhWRP7ub2_lfLCAkg3hlEwEfk7wrEmLYnR0czZRpccOV3RsbGzeUxyHPFoSFFD9YnHKEjA973oyayPosMnfs--g%3D